Potential Clinical Implications of the Urotensin II Receptor Antagonists

Potential Clinical Implications of the Urotensin II Receptor Antagonists

Urotensin II (UII) binds to its receptor, UT, playing an important role in the heart, kidneys, pancreas, adrenal gland, and central nervous system. In the vasculature, it acts as a potent endothelium-independent vasoconstrictor and endothelium-dependent vasodilator. In disease states, however, this constriction-dilation equilibrium is disrupted. There is an upregulation of the UII system in hea...

A 10 . Binding sites and structure for antagonists to the Urotensin II receptor

Monoclonal antibodies and nonpeptide antagonists to angiotensin II. Potential implications.

The introduction of agents capable of blocking the function of the renin-angiotensin system has had a profound impact on our knowledge of the physiology of the renin-angiotensin system and its role in various pathophysiological conditions, including hypertension. Saralasin and other angiotensin antagonists, peptides similar in chemical structure to angiotensin II itself, have been used since th...

Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance Short title: Urotensin II and its receptor haplotypes

We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (–605G, 143G, 3836T) was associated with higher plasma level of U-II and insulin, and higher ho...

Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients

Urotensin II and the associated urotensin II receptor (UTR) are important in the carcinogenesis of hepatocellular carcinoma (HCC). However, the clinical significance of UTR remains to be elucidated. The aim of the present study was to investigate if UTR exhibits the potential to act as a biomarker to predict the prognosis of HCC patients. The effects of UTR on motility and invasion of HCC cells...